Alteplase is a commonly used drug in the treatment of acute ischemic stroke. It is a recombinant form of tissue plasminogen activator (tPA), which is a natural clot-dissolving enzyme. Alteplase works by breaking down the clot that is blocking an artery in the brain, allowing blood to flow freely again and restoring the flow of oxygen-rich blood to the brain. Alteplase is usually given through an intravenous line, in a hospital setting, within a few hours of the onset of a stroke.
Alteplase, also known by the brand name Activase, is a medication used to treat blood clots in various parts of the body. It is a tissue plasminogen activator (tPA), which is a type of enzyme that helps to dissolve blood clots. Alteplase is most commonly used to treat:
- Acute ischemic stroke: a stroke caused by a blood clot blocking blood flow to the brain
- Acute myocardial infarction (heart attack): a heart attack caused by a blood clot blocking blood flow to the heart
- Pulmonary embolism: a blood clot that has traveled to the lungs from other parts of the body
Alteplase is given by injection into a vein or artery. The specific dose and duration of treatment will vary depending on the condition being treated.
Here are some other things to know about alteplase:
- It is a very time-sensitive medication, and it is most effective when given as soon as possible after the onset of symptoms.
- Alteplase can cause serious bleeding, so it is important to be aware of the risks and benefits before taking this medication.
- Alteplase is not for everyone, and there are a number of factors that can make it unsafe to take, such as recent surgery, history of bleeding problems, or high blood pressure.
It is important to speak to a doctor about the risks and benefits of alteplase before taking this medication.