Bazedoxifene (BZA) is a selective estrogen receptor modulator (SERM) used in the prevention of osteoporosis in postmenopausal women. BZA works by binding to estrogen receptors in the bone, preventing bone loss and reducing bone turnover, while also having a weak agonist effect on the uterus, reducing the risk of endometrial cancer. It is taken in pill form once daily. BZA has been shown to reduce the risk of vertebral fractures, and is approved by the FDA for the prevention of osteoporosis in postmenopausal women.
Bazedoxifene is a medication used to treat osteoporosis in postmenopausal women. It is also being studied for the possible treatment of breast cancer and pancreatic cancer. Bazedoxifene is a third-generation selective estrogen receptor modulator (SERM). This means that it acts like estrogen in some tissues, but not in others. For example, it acts like estrogen in the bones to help them grow stronger, but it does not act like estrogen in the uterus or breasts, which reduces the risk of side effects such as cancer.
Bazedoxifene is available in two forms:
- As a single ingredient: This form of bazedoxifene is only available in the United States and is sold under the brand name Conbriza. It is approved for the treatment of moderate to severe vasomotor symptoms (hot flashes and night sweats) in menopausal women.
- In combination with conjugated estrogens: This form of bazedoxifene is available in the United States and other countries and is sold under the brand names Duavee (in the United States) and Duavive (in other countries). It is approved for the prevention of osteoporosis in postmenopausal women who are also experiencing moderate to severe vasomotor symptoms.
It is important to note that bazedoxifene is not a cure for osteoporosis. It can help to slow the progression of the disease and reduce the risk of fractures, but it will not reverse any bone loss that has already occurred.
Here are some additional things to know about bazedoxifene:
- It is taken by mouth once a day.
- The most common side effects of bazedoxifene are leg cramps, vaginal bleeding, and breast tenderness.
- Bazedoxifene should not be taken by women who are pregnant or breastfeeding, or who have a history of blood clots, stroke, or breast cancer.
- It is important to talk to your doctor about the risks and benefits of bazedoxifene before taking it.