Chlorotrianisene (Tace) is a medication used to treat moderate to severe hot flashes that occur in women during menopause. It works by blocking the action of estrogen in the body. This medication is available in tablet form and is usually taken once a day. Common side effects of this medication include nausea, vomiting, headache, and dizziness.
Chlorotrianisene (CTA), also known as tri-p-anisylchloroethylene (TACE) and sold under the brand name Tace among others, is a nonsteroidal estrogen medication that was previously used in the treatment of menopausal symptoms and estrogen deficiency in women and prostate cancer in men, among other indications, but has since been discontinued and is now no longer available. It was taken by mouth.
Chemically, chlorotrianisene is a synthetic nonsteroidal compound of the triphenylethylene group. It is structurally related to the nonsteroidal estrogen diethylstilbestrol and to the SERMs clomifene and tamoxifen.
Chlorotrianisene was first synthesized in 1946 and introduced for medical use in 1952. It was one of the first nonsteroidal estrogens to be developed and was widely used for many years. However, it was later withdrawn from the market due to concerns about its safety, including an increased risk of cancer.
Here are some of the reasons why chlorotrianisene is no longer used:
- Increased risk of cancer: Chlorotrianisene has been linked to an increased risk of several types of cancer, including endometrial cancer, vaginal cancer, and liver cancer.
- Other side effects: Chlorotrianisene can also cause a number of other side effects, including blood clots, stroke, heart attack, and gallbladder disease.
- Safer alternatives: There are now safer and more effective treatments available for the conditions that chlorotrianisene was once used to treat.
If you are considering taking chlorotrianisene, it is important to talk to your doctor about the risks and benefits of this medication. There are many other safer and more effective treatments available for the conditions that chlorotrianisene was once used to treat.