Deferoxamine, also known as desferrioxamine, is a medication used to remove excessive iron from the body in cases of iron overload. It is administered intravenously and is often used in patients who have disorders that cause the body to absorb too much iron, such as thalassemia or hemochromatosis. It works by binding to iron molecules and allowing them to be eliminated in the urine. Side effects can include nausea, vomiting, abdominal pain, and headaches.
Deferoxamine, also known by the brand name Desferal, is a medication used to eliminate excess iron or aluminum from the body [1, 2]. It belongs to a class of drugs called chelators, which bind to specific molecules and facilitate their removal [2].
Here's a breakdown of how deferoxamine works:
- Chelation: Deferoxamine binds strongly to iron and aluminum, particularly ferric iron (Fe3+) [1, 2]. This creates a stable complex that can be eliminated from the body through the urine [1].
- Applications: Deferoxamine is used to treat two main conditions:
- Iron overload: This can occur due to frequent blood transfusions or a genetic disorder called hemochromatosis [1, 3]. In these cases, deferoxamine helps remove excess iron that accumulates in organs like the liver, heart, and pancreas, preventing damage [3].
- Aluminum toxicity: Deferoxamine can also be used to treat aluminum buildup in people with chronic kidney disease who are on dialysis [3].
Deferoxamine is typically administered by injection, either intramuscularly (into a muscle), intravenously (into a vein), or subcutaneously (under the skin) [1].
Important things to remember about deferoxamine:
- It's a prescription medication and should only be taken under the supervision of a doctor [1].
- Deferoxamine can cause side effects, so it's crucial to discuss these with your doctor before starting treatment [1].
If you have any further questions about deferoxamine or its use, it's best to consult a healthcare professional.