Etretinate (also known as Tegison) is a prescription medication used to treat severe psoriasis. It belongs to a class of drugs called retinoids, which are related to vitamin A. It works by slowing down the growth of skin cells and reducing inflammation. Etretinate is taken orally and may take several weeks to months to show improvement in the skin. It is usually taken along with other medications to treat psoriasis. Common side effects of etretinate include dry skin, redness, itching, and burning.
Etretinate is a medication that was once used to treat severe psoriasis, but it has been withdrawn from use in many countries, including the US, due to serious side effects. Here's a breakdown of its key features:
Function:
- Etretinate is a synthetic retinoid, a derivative of vitamin A. It works by affecting the growth and differentiation of skin cells, aiming to slow down the rapid and excessive skin cell turnover that occurs in psoriasis.
Why it's not widely used:
- Serious Birth Defects: Etretinate causes severe birth defects if taken during pregnancy. Due to this high risk, its use is strictly contraindicated for women who are pregnant or planning to become pregnant.
- Other Safety Concerns: Etretinate can also cause other serious side effects, including:
- Liver problems (hepatitis)
- Increased fluid pressure on the brain (pseudotumor cerebri)
- Dry skin and mucous membranes
- Bone malformations
- Depression
Alternatives:
- Safer and more effective medications are now available for treating psoriasis, such as acitretin, which is another retinoid with a less severe side effect profile. Additionally, phototherapy and biologic drugs are other treatment options.
Important Note:
- If you encounter Etretinate mentioned as a treatment for psoriasis, it's likely outdated information. It's crucial to consult a dermatologist or healthcare professional for current and safe treatment options for psoriasis.