Gefitinib is a targeted therapy used in the treatment of non-small cell lung cancer (NSCLC). It is a drug that belongs to the class of medications called tyrosine kinase inhibitors, which works by blocking the action of an enzyme called epidermal growth factor receptor (EGFR). This enzyme is involved in the growth of cancer cells and Gefitinib blocks it, thereby preventing the growth and spread of cancer cells. Gefitinib has been found to be effective in slowing down the growth of cancer and in some cases, even shrinking the tumors. It is usually taken orally, either once or twice daily.
Gefitinib, also sold under the brand name Iressa, is a medication used to treat specific types of non-small cell lung cancer (NSCLC) https://www.mayoclinic.org/diseases-conditions/lung-cancer/symptoms-causes/syc-20374620. It falls under a class of drugs called tyrosine kinase inhibitors (TKIs) https://www.cancer.gov/research/participate/clinical-trials-search/v?id=NCI-2018-01831.
Here's how Gefitinib works:
- Targets a specific protein: It targets a protein called the epidermal growth factor receptor (EGFR). EGFR is found on the surface of many cells, and in some cancers, it is overactive. This overactivity can signal cancer cells to grow and multiply.
- Blocks EGFR function: Gefitinib binds to the EGFR, blocking its function and stopping these signals from being sent. This can help slow or stop the growth of cancer cells.
Important points to remember about Gefitinib:
- Not effective for all NSCLC: Gefitinib is only effective for NSCLC with certain genetic mutations. Doctors will perform a test to see if your cancer cells have the EGFR mutations that Gefitinib targets before prescribing it.
- Comes in tablet form: It's typically taken once a day, with or without food.
- Can cause side effects: Like many medications, Gefitinib can cause side effects. Some common ones include diarrhea, rash, and dry skin.
If you have any questions about Gefitinib or whether it's right for you, it's important to speak with your doctor. They can provide you with more information about the medication and its potential benefits and risks.