Levoketoconazole (INN) is a synthetic steroid used as an investigational drug for the treatment of adrenal insufficiency and Cushing's syndrome. It is a modified form of the drug ketoconazole, with the keto group being replaced by a levo group. It is believed to be a more potent inhibitor of the enzyme CYP11B1 (11β-hydroxylase) than ketoconazole. Inhibition of 11β-hydroxylase reduces the production of cortisol, a hormone involved in the body's stress response.
Levoketoconazole, sold under the brand name Recorlev, is a medication specifically used to treat Cushing's syndrome in adults [1, 2]. It belongs to a drug class called steroidogenesis inhibitors.
Here's a breakdown of what Levoketoconazole does:
- Treats Cushing's Syndrome: This condition arises due to excess cortisol production by the adrenal glands. Levoketoconazole works by inhibiting enzymes involved in cortisol biosynthesis, thereby lowering cortisol levels and managing Cushing's syndrome symptoms [1, 2].
Key points to remember about Levoketoconazole:
- Not for Fungal Infections: Unlike its close relative ketoconazole, Levoketoconazole is not meant for treating fungal infections [2].
- Dosage and Administration: Levoketoconazole comes in tablet form and is typically taken twice daily. The exact dosage is determined by your doctor based on individual needs [2].
- Potential Side Effects: Levoketoconazole can cause side effects, including nausea, low potassium levels, liver problems, and QT interval prolongation (a heart rhythm issue) [2, 3].
- Important Warnings: Levoketoconazole can interact with other medications and is not suitable for people with certain pre-existing conditions like liver disease or a history of QT prolongation [2, 3]. It's crucial to disclose all medications you take and your medical history to your doctor before starting Levoketoconazole.