Tasonermin is a prescription medicine used to treat people with peripheral artery disease (PAD). PAD is a condition in which the arteries in the legs become narrowed or blocked, reducing blood flow to the legs. Tasonermin is a type of medicine called a recombinant tissue plasminogen activator (rt-PA). It works by helping to dissolve blood clots and increase blood flow to the legs. It is given as an injection into a vein.
Tasonermin is a medication sold under the brand name Beromun. It is a form of tumor necrosis factor alpha (TNF-alpha), a protein produced by the body's immune system [1]. It is used in isolated limb perfusion (ILP) along with melphalan, a chemotherapy drug, to treat soft tissue sarcomas of the limbs [1].
Here's a summary of how Tasonermin works:
- Isolated limb perfusion is a procedure where the blood supply to an arm or leg is isolated and a high dose of chemotherapy can be delivered directly to the tumor [2].
- Melphalan is the chemotherapy drug used to kill cancer cells [2].
- Tasonermin is thought to work in several ways, including directly killing tumor cells, damaging the blood vessels that supply tumors, and stimulating the immune system to attack the cancer [2].