Trastuzumab

Trastuzumab is a prescription medicine used to treat breast cancer. It is a type of targeted therapy called a monoclonal antibody. It works by attaching to a specific protein called human epidermal growth factor receptor 2 (HER2) on the surface of certain cancer cells. This helps to stop the cancer cells from growing and spreading. Trastuzumab is usually given together with other cancer treatments.

Trastuzumab, also known by the brand name Herceptin, is a medication used in targeted cancer therapy for specific types of breast cancer and stomach cancer [1, 2]. Here's a breakdown of its key aspects:

Function:

• Monoclonal antibody: Trastuzumab is a lab-made protein that targets a specific protein (HER2 receptor) found on the surface of some cancer cells [1].

Cancers treated:

• HER2-positive breast cancer: Trastuzumab is most commonly used to treat breast cancer where there are high levels of the HER2 protein on the surface of cancer cells [1, 2]. This type of breast cancer is often more aggressive.
• HER2-positive stomach cancer: In some cases, it can also be used in combination with other medications to treat stomach cancer with HER2 overexpression [2].

How it works:

• Trastuzumab binds to the HER2 receptor on cancer cells, blocking its signaling pathway [1]. This can slow down or stop the growth of HER2-positive cancer cells.
• It may also trigger the immune system to attack the HER2-positive cancer cells [2].

Important things to know about Trastuzumab:

• It's typically administered intravenously (injected into a vein) by a healthcare professional [1].
• Common side effects include fatigue, diarrhea, nausea, headache, muscle aches, and fever [2].
• There can be more serious side effects, including heart problems and infusion reactions. It's crucial to be monitored by a doctor while receiving Trastuzumab [2].
• It can interact with other medications, so be sure to tell your doctor about all medications and supplements you take before starting Trastuzumab [2].