International Numbering System (INS) for Food Additives:1518
Food additives Europe numbers: E1518
Functional Category
Humectant; plasticizer; solvent.
Applications in Pharmaceutical Formulation
Triacetin is mainly used as a hydrophilic plasticizer in both aqueous and solvent-based polymeric coating of capsules, tablets, beads, and granules; typical concentrations used are 10–35% w/w.(1,2) Triacetin is used in cosmetics, perfumery, and foods as a solvent and as a fixative in the formulation of perfumes and flavors.
Description
Triacetin is a colorless, viscous liquid with a slightly fatty odor.
Stability and Storage Conditions
Triacetin is stable and should be stored in a well-closed, nonmetallic container, in a cool, dry place.
Incompatibilities
Triacetin is incompatible with metals and may react with oxidizing agents. Triacetin may destroy rayon fabric.
Safety
Triacetin is used in oral pharmaceutical formulations and is generally regarded as a relatively nontoxic and nonirritant material at the levels employed as an excipient.(3) LD50 (dog, IV): 1.5 g/kg(4) LD50 (mouse, IP): 1.4 g/kg LD50 (mouse, IV): 1.6 g/kg LD50 (mouse, oral): 1.1 g/kg LD50 (mouse, SC): 2.3 g/kg LD50 (rabbit, IV): 0.75 g/kg LD50 (rat, IP): 2.1 g/kg LD50 (rat, oral): 3 g/kg LD50 (rat, SC): 2.8 g/kg