Vandetanib

Vandetanib is a prescription medication used to treat certain types of thyroid cancer. It works by blocking certain proteins that help cancer cells grow and spread. Vandetanib is usually taken once daily with or without food. Common side effects of vandetanib include nausea, diarrhea, hair loss, and skin rash.

Vandetanib, sold under the brand name Caprelsa, is a medication used to treat specific types of thyroid cancer and a rare lung cancer. Here's a breakdown of its key aspects:

• Conditions treated:
  • Medullary thyroid carcinoma (MTC): Vandetanib is primarily used for treating a type of thyroid cancer called MTC. This cancer originates in the hormone-producing cells of the thyroid gland.
  • Non-small cell lung cancer (NSCLC): It's also approved for treating a specific subtype of NSCLC with a genetic mutation in the EGFR or HER2 gene. These mutations can promote uncontrolled cell growth in lung cancer.
• Mechanism of action: Vandetanib belongs to a class of drugs called tyrosine kinase inhibitors (TKIs). TKIs work by blocking enzymes called tyrosine kinases, which are essential for the growth and survival of various cancer cells. By inhibiting these enzymes, vandetanib helps slow down or stop the growth and spread of cancer cells.
• Administration: Taken orally, typically as a capsule once daily with or without food.

Important considerations:

• Genetic testing for NSCLC: For NSCLC treatment, genetic testing is crucial to determine the presence of EGFR or HER2 mutations. Vandetanib is only effective for NSCLC with these specific mutations.
• Potential side effects: Vandetanib can cause various side effects, including diarrhea, rash, headache, fatigue, and high blood pressure. Some side effects may require dose adjustments or medication interruptions. Regular monitoring by a doctor is essential while taking vandetanib.
• QT prolongation: Vandetanib can affect the heart rhythm (QT prolongation on ECG). Your doctor will likely perform ECG tests before and during treatment.